Although immunosuppressive medications are effective in the treatment of lupus, your doctor can discuss with you the risk of this possible relationship and the use of the immunosuppressive medications involved in your advised treatment. For this reason, these drugs are sometimes called “steroid-sparing” medications or “adjuvant” (helping) drugs. Men who want to have children should also talk to their doctor about stopping the medication. It can either be prescribed alone or in combination with other treatments, such as methotrexate; often leflunomide is prescribed for patients who do not respond well to methotrexate. Therefore, it is important that you wash your hands regularly, maintain good personal hygiene, and notify your doctor at the first sign of any infection or fever. Gastrointestinal ulcers or cancers such as cancer of the colon may slowly ooze blood and can also cause anemia. Lupus can lead to numerous health complications and, in serious cases, can even become life-threatening. Race and ethnicity: Women of color have higher incidences of lupus than do Caucasian women of primarily Northern European descent. However, the likelihood of these side effects does increase as your dosage goes up. Your doctor should perform blood tests at this time to determine whether your dosage should be altered. Many of the side effects of methotrexate involve the fact that the medication works by interfering with the production of folic acid in your body. People taking methotrexate usually feel improvements in 3-6 weeks, but it can take up to 3 months to feel the full benefit of the drug. The starting dose of cyclosporine depends on your body weight (usually 2.5 milligrams [mg] per kilogram [kg] per day). DMARDs not only reduce this pain and swelling, but they may also be able to decrease long term damage to your joints. Medications that can interact with leflunomide include cholestyramine (Questran), tolbutamide (Orinase), and rifampin (Rifadin, Rimactane), so be sure to tell your doctor if you are on these medications. Your doctor can speak with you about this risk and any other concerns you may have. Be sure to speak with your doctor before taking getting any vaccines or having surgery. If the diarrhea persists, she/he may lower your dosage. Thus, prescribing Cellcept for your kidney involvement is not meant to introduce new risk factors, but rather to treat the seriousness of your condition at this moment in time. A similar warning was issued regarding the drug rituximab (Rituxan) in late 2006. If you are pregnant, may become pregnant, or are breast-feeding, your doctor will strongly recommend that you stop taking Cellcept due to the risk of birth defects. Women who are pregnant, may become pregnant, or are breastfeeding should speak with their doctor before taking leflunomide, since this medication can cause serious birth defects and complications. It takes some time for the medication to build up in your body, so some doctors may prescribe something called a “loading dose” when you first begin to take leflunomide. Patients with IMHA often need oxygen-carrying fluids to support them through the first few days of care until immunosuppression begins to control the disease process. As a result, methotrexate hinders the growth of certain cells, including those of the immune system. This medication is also steroid-sparing, meaning it can be used in conjunction with steroids to lower the dose of steroid therapy and thus also lower the associated side effects. Leukeran is usually taken by mouth and is commonly used in Europe and developing countries. Imuran is “steroid-sparing,” which means that it may allow for a reduction of the amount of steroid being taken. What to Know About Rheumatic Disease and the COVID-19 Coronavirus, Lupus and Contraception: Essentials for Patients, Pregnancy and Lupus: Risks and Best Practices, Lupus Across the Lifespan: SLE in Children, Teenagers, Adults and Seniors, Top 10 Series: Lupus and Cardiovascular Disease (CVD), Top 10 Series: Lupus and Heart Conditions, Top 10 Series: Top 10 Points Lupus Patients Should Know About Autoimmune Thyroid Diseases, Lupus and Joint Replacement Surgery: What You Should Know, Lupus & Medications: An HSS Facebook Chat, Belimumab (Benlysta®): The First FDA-Approved Biologic Agent for Lupus, How to Use Capsaicin (Pepper Creams) for Joint Pain, Steroid Side Effects: How to Reduce Drug Side Effects of Corticosteroids, Complementary and Alternative Therapies for Pain.

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